Prof. Pamoda Ratnaweera

Prof. Pamoda Bhasini Ratnaweera

Professor

Ph.D. in Natural Products Chemistry (Colombo, collaborated with University of British Columbia, Vancouver, Canada)
B.Sc.Hons. (First Class) in Zoology (Colombo)

Email :pamoda@uwu.ac.lk / pamoda.b@gmail.com
Phone : +94 55 222 6676

  • Bioactive Secondary Metabolites
  • Structure Elucidations
  • Bioassays
  • Diversity of Life

Peer Reviewed/Indexed Research Articles


Pamoda B. Ratnaweera, D. P. Hasini Madhushika, J.M. Nisansala M. Jayasundara, David E. Williams, E. Dilip de Silva and Raymond J. Andersen (2022). Antifeedant properties and contact toxicities of the trichocellins A-I and B-II from a Trichoderma reesei against Plutella xylostella larvae. International Journal of Tropical Insect Science 42, 845-854. https://doi.org/10.1007/s42690-021-00608-2


Uthpala S. Deshapriya, D.L. Senal Dinuka, Pamoda B. Ratnaweera, Chinthaka N. Ratnaweera (2021). In silico study for prediction of novel bioactivities of the endophytic fungal alkaloid, mycoleptodiscin B for human targets. Journal of Molecular Graphics and Modelling 102: 107767. https://doi.org/10.1016/j.jmgm.2020.107767


Pamoda B. Ratnaweera, J.M. Nisansala M. Jayasundara, H.H.M. Suseema D. Herath, David E. Williams, Sasini U. Rajapaksha, K.M.D.W. Prabath Nishantha, E. Dilip de Silva and Raymond J. Andersen (2020). Antifeedant, contact toxicity and oviposition deterrent effects of phyllostine acetate and phyllostine isolated from the endophytic fungus Diaporthe miriciae against Plutella xylostella larvae. Pest Management Science 76:1541-1548. https://doi.org/10.1002/ps.5673


Rukshana Mohamad-Ramshan, Pamoda B. Ratnaweera, David E. Williams, E. Dilip de Silva, Raymond J. Andersen (2019). Stable isotope feeding studies reveal a steroid 5(67) abeo ring contraction biogenesis for the antibiotic solanioic acid produced by cultures of the fungus Rhizoctonia solani. The Journal of Antibiotics 72: 246-251. https://doi.org/10.1038/s41429-018-0137-9


Pamoda B. Ratnaweera, R. Chandula Walgama, Kinkini U. Jayasundera, Suseema D. Herath, S. Abira, David E. Williams, Raymond J. Andersen, E. D. de Silva (2018). Antibacterial activities of endophytic fungi isolated from six Sri Lankan plants of the family Cyperaceae. Bangladesh Journal of Pharmacology 13: 264-272. https://doi.org/10.3329/bjp.v13i3.36716


David E. Williams, Niranjan W. Gunasekara, Pamoda B. Ratnaweera, Zehua Zheng, Samantha Ellis, Sarah Dada, Brian O. Patrick, Ravi L.C. Wijesundera, Chandrika m. Nanayakkara, Wilfred A. Jefferies, E. Dilip de Silva, Raymond J. Andersen (2018). Serpulanines A to C, N-Oxidized Tyrosine derivatives isolated from the Sri Lankan fungus Serpula sp.: Structure elucidation, synthesis and histone deacetylase inhibition. Journal of Natural Products 81, 78-84. DOI:https://dx.doi.org/10.1021/acs.jnatprod.7b00680


Ryan M. Centko, Pamoda B. Ratnaweera, Christina Tysoe, Stephen G. Withers, E. Dilip de Silva, Raymond J. Andersen (2017). Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri Lanka. Phytochemistry Letters 22:76-80. https://dx.doi.org/10.1016/j.phytol.2017.09.004


Yasara de Mel, Sashini Perera, Pamoda B. Ratnaweera, Chanika D. Jayasinghe (2017). Novel insights of toxicological evaluation of herbal medicine: Human based toxicological assays. Asian Journal of Pharmacy and Pharmacology 3(2): 41-49.


Ranga K. Dissanyaka, Pamoda B. Ratnaweera, David E. Williams, C. Dilrukshi de Silva, Ravi L. C. Wijesundera, Raymond J. Andersen, E. Dilip de Silva (2016). Antimicrobial activities of endophytic fungi of the Sri Lankan aquatic plant Nymphaea nouchali and chaetoglobosin A and C, produced by the endophytic fungus Chaetomium globosum. Mycology: An International Journal of Fungal Biology 7(1):1-8. https://dx.doi.org/10.1080/21501203.2015.1136708


Pamoda B. Ratnaweera, David E. Williams, E. Dilip de Silva and Raymond J. Andersen (2016). Antibacterial metabolites from the Sri Lankan demosponge derived fungus Aspergillus flavipes. Current Science 3(9):1473-1479. https://www.jstor.org/stable/24909158


Ranga K. Dissanayake, Pamoda B. Ratnaweera, David E. Williams, C. Dilrukshi Wijayarathne, Ravi L. C. Wijesundera, Raymond J. Andersen, E. Dilip de Silva (2016). Antimicrobial activities of mycoleptodiscin B isolated from endophytic fungus Mycoleptodiscus sp. of Calamus thwaitesii Becc. Journal of Applied Pharmaceutical Science 6(1):1-6. DOI: https://dx.doi.org/10.7324/JAPS.2016.600101


Pamoda B. Ratnaweera, E. Dilip de Silva, Ravi L. C. Wijesundera and Raymond J. Andersen (2016). Antimicrobial constituents of Hypocrea virens an endophyte of the mangrove-associate plant Premna serratifolia L. Journal of National Science Foundation, Sri Lanka 44(1):43-51. DOI: https://dx.doi.org/10.4038/jnsfsr.v44i1.7980


Pamoda B. Ratnaweera, David E. Williams, Brian O. Patrick, E. Dilip de Silva and Raymond J. Andersen (2015). Solanioic acid, an antibacterial degraded steroid produced in culture by the fungus Rhizoctonia solani isolated from tubers of the medicinal plant Cyperus rotundus. Organic Letters 17:2074-2077.DOI: https://dx.doi.org/10.1021/acs.orglett.5b00596


Pamoda B. Ratnaweera, E. Dilip de Silva, David E. Williams, Raymond J. Andersen (2015). Antimicrobial activities of endophytic fungi obtained from the arid zone invasive plant Opuntia dillenii and the isolation of equisetin, from endophytic Fusarium sp. BMC Complementary and Alternative Medicine 15:220. DOI: https://dx.doi.org/10.1186/s12906-015-0722-4


Pamoda B. Ratnaweera, David E. Williams, E. Dilip de Silva, Ravi L. C. Wijesundera, Doralyn D. Dalisay and Raymond J. Andersen (2014). Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology: An International Journal of Fungal Biology 5(1): 23-28. https://dx.doi.org/10.1080/21501203.2014.892905


Mark S. Harvey, Pamoda B. Ratnweera, Preethi V. Udagama and Mayuri R. Wijesighe (2012). A new species of the pseudoscorpion genus Megachernes (Pseudoscorpiones: Chernetidae) associated with a threatened Sri Lankan rainforest rodent, with a review of host associations of Megachernes. Journal of Natural History 46:2519-2535.https://dx.doi.org/10.1080/00222933.2012.707251


Pamoda B. Ratnaweera, Mayuri R. Wijesinghe and Preethi V. Udagama-Randeniya (2010). Parasitic associations of a threatened, endemic rainforest rodent Mus mayori pococki (Sri Lanka spiny rat). Journal of Threatened Taxa 2(6): 901-907.


Pamoda B. Ratnaweera and Mayuri R. Wijesinghe (2009). Effect of food quality and availability on rainforest rodents of Sri Lanka. Journal of Threatened Taxa 1(12): 581-588.



Book Chapters


Pamoda B. Ratnaweera, E. Dilip de Silva (2017). Endophytic fungi: A remarkable source of biologically active secondary metabolites. In: Maheshwari D., Annapurna K. (eds) Endophytes: Crop productivity and protection. Sustainable development and biodiversity, Vol 16. Chapter 9, p.191-212, Springer, Cham.



Patents


Title of the invention: A method for isolating phyllostine acetate and analogs from the fungus Diaporthe miriciae, its compositions, and its applications for the control of the agricultural insect pest Plutella xylostella.
Inventors: P.B. Ratnaweera, J.M.N.M. Jayasundara, H.H.M.S.D. Herath, D.E. Williams, S.U. Rajapaksha, K.M.D.W.P. Nishantha, E.D. de Silva, R.J. Andersen
Patent No. 21424
Date of filing: 04/11/2020


Title of the invention: A novel method for isolating Mycoleptodiscin B from an endophytic fungus Mycoleptodiscus sp. isolated from leaves of Calamus thwaitesii and its application against human pathogenic bacteria.
Inventors: D.M.R.K Dissanayake, P.B. Ratnaweera, D.E. Williams, C.D. Wijerathna, R.L.C. Wijesundera, R.J. Andersen, E.D de Silva
Patent No. 18931
Date of filing: 15/08/2016


Title of the invention: A method for isolating Solanioic acid from the fungus Rhizoctonia solani, its compositions and its antibacterial activity against pathogenic bacteria.
Inventors: P.B. Ratnaweera, D.E. Williams, R.J. Andersen, E.D de Silva, B.O. Patrick
Patent No. 18450
Date of filing: 01/10/2015



Conference Proceedings/Abstracts


K. H. T. P. Kumarasinghe, T. Pavalakantharasa, J. M. N. M. Jayasundara, P. B. Ratnaweera (2020) Antibacterial cytochalasin B from endophytic Curvularia lunata isolated from Cyperus iria of Sri Lanka. Proceedings of the 1st International Conference on Frontiers in Chemical Technology. 20-22 July, 2020, Colombo, Sri Lanka, 23p.


H. P. Sandeepani, P. B. Ratnaweera (2020) Antibacterial activity of entomopathogenic fungi isolated from Vespa affinis and Apis dorsata in Sri Lanka (2020) Proceedings of the 1st International Conference on Frontiers in Chemical Technology. 20-22 July, 2020, Colombo, Sri Lanka, 29p.


D. P. H. Madhushika, J. M. N. M. Jayasundara, P. B. Ratnaweera, D. E. Williams, E. D. de Silva, R. J. Andersen (2020) Antibacterial activities of peptaibols, trichocellin A-I and B-II, isolated from the endophytic fungus Trichoderma reesei. Proceedings of the 1st International Conference on Frontiers in Chemical Technology. 20-22 July, 2020, Colombo, Sri Lanka, 30p.


D. P. H. Madhushika, J. M. N. M. Jayasundara, P. B. Ratnaweera, E. D. de Silva (2020) Antifeedant activity and contact toxicity of the two peptaibols, trichicellin A-I and B-II isolated from the endophytic fungus Trichoderma reesei. Proceeding of the International Research Conference of Uva Wellassa University, July 29-30, 2020, Badulla, Sri Lanka, 25p.


R. D. U. S. Deshapriya, D. L. S. Dinuka, C. N. Ratnaweera, P. B. Ratnaweera (2019) Activity of several endophytic fungal extracts from Sri Lanka against Staphylococcus aureus; an in-silico assessment. The 12th International Research Conference 2019, General Sir John Kotelawala Defense University, Colombo, Sri Lanka, 211p.



National Level


Member of the Jury for ‘Sahasak Nimavum 2021’ National Online Invention and Innovation Competition conducted by the Sri Lanka Inventors Commission (SLIC)


Chief Examiner of G.C. E. Advanced Level (A/L) Biology paper marking (2020)


Vice President, Council of the Institute of Biology, Sri Lanka (Sep 2020 to Sep 2022)


Secretary, Council of the Institute of Biology, Sri Lanka (Sep 2017-Sep 2020)


Council Member of the Institute of Biology, Sri Lanka (Sep 2015- to Sep 2022)


Managing Editor, Sri Lankan Journal of Biology (SLJB) (From its inception in 2016-2022)


Institutional Coordinator of the ‘Asian symposium on medicinal plants, spices and other natural products XVI (ASOMPS XVI)’ on 12-14 December 2018 at BMICH


University Coordinator for the Inter-University Biology Quiz Competition 2018 & 2020, by the Institute of Biology, Sri Lanka


Organizing committee member and University coordinator of the Biology Challenge 2020 organized by the Institute of Biology, Sri Lanka


Center Coordinator-Inter University Chemistry Quiz Competition & Chemistry Olympiad 2018-2019 organized by the Institute of Chemistry, Ceylon.


Visiting Research Scientist, Department of Chemistry, University of British Columbia, Vancouver, Canada (2012-2016). Prof. Raymond Andersen Group-Marine natural products research laboratory and Prof. Katherine Ryan Group-Biosynthetic enzyme laboratory


University Level


Member of the University Curriculum Development Committee July 2023-to date


Member of the Examination Manual Preparation Committee 2023


Chairperson, Board of Study/Life Sciences, Faculty of Applied Sciences, Uva Wellassa University. August 2020 to-date.


Chairperson, Faculty Higher Degrees Committee, Faculty of Applied Sciences, Uva Wellassa University. August 2019-August 2021


Secretary, Higher Degrees Committee, Faculty of Applied Sciences, Uva Wellassa University. August 2018- August 2019


Chairperson, Housing Committee of Uva Wellassa University, Badulla. March 2019-February 2021


Coordinator of the proposed BSc. external degree programme, Department of Science and Technology, Faculty of Applied Sciences, Uva Wellassa University.


Coordinator of the proposed BSc ‘Biorprocess Engineering’ degree programme, Department of Science and Technology, Faculty of Applied Sciences, Uva Wellassa University.


Activity Coordinator (Activity 03) of the AHEAD Faculty Development Project of 120 Million, Uva Wellassa University from 2019-2022


Student Counsellor (Utilities and Logistical Support) from 01st October 2016- 30th September 2017


Academic representative for Centre for Gender Equity/Equality 01st November 2016- 31st October 2017


Member of the working committee of University Industry Coordination Cell 07th October 2016-06th October 2017.


Track/Theme Coordinator of the ‘Bioprocess Track’ International Research Symposium of Uva Wellassa University (IRSUWU) 2016-2018 (for 3 consecutive years)



Memberships


  • Chartered Biologist, by the Institute of Biology, Sri Lanka (C. Biol)
  • Life member of the Institute of Biology, Sri Lanka (M. I. Biol.)
  • Life member of the Institute of Chemistry, Ceylon (M. I. Chem. C.)
  • Life member of the Sri Lanka Association for the Advancement of Science – 8025/D (SLAAS)
  • Member of the National Database on Science and Technology Personnel, National Science Foundation (NSF), Sri Lanka – NSF/STMIS/08/3139
  • Life member of the Young Scientist Forum -Y/R/35 (YSF-NASTEC)
  • Life member of the Field Ornithology Group of Sri Lanka (FOGSL)
  • Life member of the Allergy and Immunology Society of Sri Lanka (AISSL)

Awards


  • SUSRED Award (2021) awarded by the National Science Foundation (NSF) Sri Lanka
  • Professor M. U. S. Sultanbawa Award for Research in Chemistry (2021) awarded by the Institute of Chemistry Ceylon.
  • Chandrasena Memorial Award (2019) for an exceptional research contribution of an original nature in the field of Organic Chemistry and related areas such as Biochemistry, Pharmacognosy, Molecular Biology and Bioactivity studies, offered by the Institute of Chemistry, Ceylon.
  • Merit Award for Scientific Publications (2018) by NRC
  • Vice Chancellors Award for Most Outstanding Young Researcher of the Year 2017
  • GRC Postgraduate Research Award (2016) awarded by SLAAS
  • President’s Award for Scientific Publications (2015) by NRC
  • UWU research awards (2016-2020) – for Scientific publications in indexed journals in 2015-2019
  • Gulamhusein A.J. Noorbhai Gold Medal for Zoology for highest competence at the Special Degree Examination in Zoology (2007) – University of Colombo, Sri Lanka
  • Gulamhusein A.J. Noorbhai Gold Medal for Zoology Research Project (2007) – highest mark for the research project with an “A” grade 2007- University of Colombo, Sri Lanka.
  • D.P.P. Samarasekera Peace Prize (2007) (An open award for the whole university) – University of Colombo, Sri Lanka.
  • Studentship holder for best academic excellence, at the first-year examination in the Faculty of Science (2004-2007) – University of Colombo, Sri Lanka.

  • SCT 222-2 Biochemistry
  • SCT 223-3 Diversity of Life
  • SCT 321-2 Bioenergetics in Food Metabolism and Exercise
  • SCT 329-2 Organic Synthesis and Spectroscopy in Bioprocess Technology
  • SCT 337-2 Natural Products Biosynthesis and Separation Techniques
  • SCT 381-2/382-2 MRT 361-2 Research Methodology and Scientific Writing
  • GRD 602-2 Research Methodology and Scientific Writing